Rejuran is a polynucleotide product, made from purified salmon DNA fragments, used in Korea and elsewhere as a skin booster. In the United States it holds no FDA approval for injection. That single fact shapes everything on this page, so it comes first.
What polynucleotides are, and are not
Plain language. Polynucleotides are short chains of DNA, purified from salmon, that are studied for their effect on skin repair and hydration. Interest in them is genuine. Regulatory position in the United States is separate from that interest: injectable polynucleotide products have not been approved here, so an injection of Rejuran is not something a US practice can offer as an approved treatment. Topical polynucleotide formulas are a different matter.
Common concerns
- Fine lines and wrinkles
- Fine lines around the eyes
- Skin that looks thin, crepey
- Dull texture
- Pores that look enlarged
- Dry skin
- Early lines around the mouth
- Uneven tone and texture
- Post acne marks
Where the evidence stands
Most published studies on polynucleotides come from South Korea and other markets where the injectables are licensed. They tend to be small, short and run by single centers, and they report improvements in texture, hydration and fine lines.
That is encouraging. It is not the same as settled, well replicated evidence. In short. Promising, early, and not approved for injection in the United States. Treat any stronger claim carefully.
Good to know
- Polynucleotides come from purified salmon DNA
- Injectable Rejuran carries no FDA approval here
- Most published research comes from outside the United States
- Study groups have been small
- Topical formulas are available here
- Practice varies from provider to provider
- Ask exactly what product is being used
- Consider it emerging rather than settled, and plan accordingly
Common questions
Is Rejuran approved by the FDA in the United States?
No. Injectable polynucleotide products, including Rejuran, do not hold FDA approval for cosmetic injection in the United States. They are approved in South Korea and available in several other countries. Approval in one country does not carry over to another.
So what is actually available to me here?
Ask your provider. Every time. Topical polynucleotide formulas can be used on the skin, often after microneedling. What any individual practice offers, and under what name, is a question to ask directly.
What is known about its safety?
Reported side effects in published studies are mostly local and short lived: redness, swelling, bruising and small bumps at injection points. Long term data in the United States is limited.
Why do I hear so much about Rejuran if it is unapproved here?
Because it is widely used in Korea and travels fast through social media and beauty press. Popularity abroad is not evidence of approval at home, and the two get blurred easily. If you have seen it recommended online, bring the post to your consultation and ask what applies here.
What else could give me a similar result?
Several approved options address texture, hydration and fine lines, including microneedling, resurfacing lasers and injectable skin treatments cleared for use here. Which one suits your skin is a consultation conversation.
Bring your questions to consultation
It is easier to decide when you know where a treatment actually stands. Polynucleotides are interesting and worth watching. What is available to you in this country today is a narrower thing than the conversation around them suggests. Ask hard questions.Come in with the name you read about and leave knowing what it is, what it is not, and which approved options get closest to what you want.